The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.
Jul-Sep ; 3 Popa" Iaşi. PMID: Abstract The genitals and breast cancers takes an important place in the women's pathology, either through the increase numbers of cases and also through the mortality induced by these cases. Aim: The descriptive evaluation of the genitals and breast cancers and there risk factors to women from North-Eastern region of Romania.
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We have used a special questionnaire for the evaluation of the risk factors. Trained interviewers identified and questioned cases.
The following parameters were assessed: marital status, educational level, age at menarche, age at the first sexual genital hpv infection cancer, age at first birth, parity, spontaneous abortions, period of breast-feeding, menopausal status, age at menopause, family history of cancers, personal history of gynecologic diseases, body mass index, oral contraceptive use, hormone replacement therapy use, environmental exposures, Pap test. Results: The following cases' repartition on diagnostic types was observed: breast cancer 41 casescervical cancer 24 casesendometrial cancer 12 cases and ovarian cancer 7 cases.
The cases mean of age was Conclusion: The diagnostic, educational level, age at first birth over 30 years was directly correlated with histological types. In our study, the mains factors correlated with types of neoplasia were obesity, HPV infections, stage and age.