Drug toxicity

Source: Clujul Medical. Dec, Vol. Author s : Chifan, Maria Abstract: Metronidazole is one of the most used drugs in medical practice, due to its large antimicrobial specter, as well as its antiparasitic actions, being the drug chosen for genital trichomoniasis drug toxicity men, as well as in women. This is not a nontoxic drug.

There is a correlation between dose, duration of treatment and the moment of clinical severe manifestations associated to toxicity. Metronidazole and its derivatives have an action against protozoa, as well as bacterial microorganisms. Metronidazole is an antibiotic also used in veterinary medicine, to treat various infections: anaerobic bacterial infections, protozoa infections, gastritis associated with helicobacter, hepatic encephalopathy.

In addition, towards the anti protozoa and bacterial proprieties, metronidazole is considered to have immunomodulatory effects, being frequently used in treating intestine inflammatory diseases in dogs, as well as in cats. Metronidazole is a drug with acceptable toxicity on reproduction; new studies are necessary in order to determine and deepen its implications to embryo-fetal development.

As a rule, it is not administrated during the first pregnancy trimester when the embryogenesis process takes place, neither the women who breastfeed because it gets through milk, to fetus. When administrated during the third trimester to pregnant women with bacterial vaginosis, it prevents various pregnancy complications: preterm birth, premature and early membrane rupture and intra-amniotic infection. Copyright of Clujul Medical is the property of Cluj Medical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission.

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